Working with a segment
Please create your segment(s) first.
See this article https://www.easy-mails.net/article/how-create-segment
on how to do that.
To avoid the SPAM folder you need to stop mailing your autoresponder messages after a while.
Let's say, you want to stop sending autoresponder messages after someone did not open your messages after 30 days,
you can decide to ONLY send the rest of the messages to people who actually OPEN your messages.
Create a new autoresponder campaign, select your Lst, and then choose the segment. For Instance "openers"
Now only engaging subscribers will get your emails.
You can decide to send only broadcast emails to your whole list.
if they are not opening your email after half a year, make sure you delete them from your account.